Model Number

SKY-08

CAS:114977-28-5     

Characters  A:White to off-white crystalline powder                 

B:solubility  Insoluble in water ,soluble in ethanol and acetone  

Specific rotation             ﹣42°～﹣48°                               Identification

1 :  IR                  The same to check sample                      

2：UV                     λmax233nm,                               

3：Colour reactions         postive  reactions                           

4: Hplc                 retention times is same as the standard sample        

TESTS

1： Impurities        total impurities is not more than 1.0%             0.55%

                    single impurity is not more than 0.5%             0.20%

2：water             NMT3.0%                                   0.81%

3：Sulphated ash      NMT 0.1% w/w                           0.03%

4：heavy metal             NMT 20ppm                                

5: Organic volatile   A: Methylene chloride NMT0.06%                0.002%

impurities        B:Pyridion NMT0.02%                            0.005%                                                          

                C:Toluene NMT 0.089%                            0.03%

Assay         98.0%～102.0%                                    99.7%

                                                                          Storage:stored at 2-8℃ and in a hermetical,light-resistant area.

Also we supply intermediate:

Benzenepropanoic acid

Formula： C49 H55 Cl6 N O18

CAS No:114915-14-9

Docetaxel belong to the semi-synthetic taxane anticancer drug, which essentially "frozen" by the microtubule skeleton composed of cells to suppress cancer cells split. In a cell cycle microtubule polymerization and depolymerization, docetaxel promote microtubule polymerization and depolymerization to inhibit in order to prevent a large number of cancer cell division, leading to the death of cancer cells.
Docetaxel in the domestic indications:

1:the failure of chemotherapy for early advanced or metastatic breast cancer treatment. Unless belong to the clinical taboos. Early treatment should include the anthracycline anti-cancer drugs.
2: with cisplatin-based chemotherapy for advanced or metastatic failure of non-small cell lung cancer treatment

Disease associated with the failure of the election period chemotherapy for advanced metastatic non-small cell lung failure of chemotherapy for advanced